文章
醫療新知 > HR+/HER2- 型 晚期乳癌治療新喜訊!

HR+/HER2- 型 晚期乳癌治療新喜訊!

06-02-2023
HR+/HER2- 型 晚期乳癌治療新喜訊!
HR+/HER2- 型 晚期乳癌治療新喜訊!
CDK4/6抑製劑的出現改變了荷爾蒙受體陽性、第二型人類表皮生長因子受體陰性(HR+/HER2-)晚期乳癌治療的格局,並成為標準內分泌聯合治療方案重要元素,但是對於疾病進展快、腫瘤較大、徵狀嚴重的惡性乳癌患者,化療仍是標準的治療選擇。與單藥化療相比,聯合化療具有更高的客觀緩解率(Overall Response Rate, ORR)和更長的無惡化存活期(Progression-Free Survival, PFS),成為這些患者之傳統首選治療方案。

在 2022年12月的世界性乳癌醫學會議SABCS 中,台灣乳癌權威盧彥伸教授公佈第二期臨床試驗RIGHT Choice的結果。RIGHT Choice是首個針對轉移性HR+/HER2- 惡性乳腺癌患者使用聯合化療對比荷爾蒙療法聯合CDK4/6抑制劑的第二期臨床隨機對照試驗。為這類患者帶來化療以外之選擇。

此資訊由諾華製藥(香港)有限公司全力支持
HK2212283919

———
1. O’Shaughnessy J. Extending survival with chemotherapy in metastatic breast cancer. Oncologist. 2005;10 Suppl 3:20-29. doi:10.1634/theoncologist.10-90003-20
2. Lu YS, Mahidin EIBM, et al. Primary results from the randomized Phase II RIGHT Choice trial of premenopausal patients with aggressive HR+/HER2− advanced breast cancer treated with ribociclib + endocrine therapy vs physician’s choice combination chemotherapy. Presented at the 2022 San Antonio Breast Cancer Symposium (SABCS). December 6-10, 2022. Abstract # GS1-10.
3. Yardley DA, Yap YS, et al. Pooled exploratory analysis of survival in patients (pts) with HR+/HER2- advanced breast cancer (ABC) and visceral metastases (mets) treated with ribociclib (RIB) + endocrine therapy (ET) in the MONALEESA (ML) trials. Presented at the European Society of Medical Oncology (ESMO) Congress. September 9-13, 2022. Abstract #205P.
4. Neven P, Fasching PA, et al. Updated overall survival (OS) results from the first-line (1L) population in the Phase III MONALEESA-3 trial of postmenopausal patients with HR+/HER2- advanced breast cancer (ABC) treated with ribociclib (RIB) + fulvestrant (FUL). Presented at the European Society for Medical Oncology (ESMO) Breast Cancer Congress. May 4, 2022. Abstract #LBA4, May 4, 2022.
5. Hortobagyi, et al. Overall Survival With Ribociclib Plus Letrozole in Advanced Breast Cancer. N Engl J Med 2022; 386:942-50.
6. Hortobagyi, et al. Overall survival (OS) results from the phase III MONALEESA (ML)-2 trial of postmenopausal patients with hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2−) advanced breast cancer (ABC) treated with endocrine therapy (ET) ± ribociclib. Presented at the European Society of Medical Oncology (ESMO) Congress, September 16-21, 2021. Abstract #LBA17.
7. Im, SA. et al. Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer. N Engl J Med 2019; 381:307-316.
8. Slamon DJ, Neven P, Chia S, Fasching PA, De Laurentiis M, Im S-A, et al. Overall survival with ribociclib plus fulvestrant in advanced breast cancer. N Engl J Med. 2020;382(6):514–24.
9. Slamon, DJ, et al. Overall survival (OS) results of the Phase III MONALEESA-3 trial of postmenopausal patients (pts) with hormone receptor–positive (HR+), human epidermal growth factor 2–negative (HER2−) advanced breast cancer (ABC) treated with fulvestrant (FUL) ± ribociclib (RIB). Presented at the European Society of Medical Oncology (ESMO) Congress, September 29, 2019, Barcelona, Spain. Abstract #LBA7.
10. Slamon D, Neven P, Chia S, et al. Updated overall survival (OS) results from the Phase III MONALEESA-3 trial of postmenopausal patients (pts) with HR+/HER2− advanced breast cancer (ABC) treated with fulvestrant (FUL) ± ribociclib (RIB. Presented at the American Society of Clinical Oncology (ASCO) Annual Meeting, June 5, 2021. Abstract #1001.
11. Tripathy D, Im S-A, Colleoni M, et al, Updated overall survival (OS) results from the phase III MONALEESA-7 trial of pre- or perimenopausal patients with HR+/HER2− advanced breast cancer (ABC) treated with endocrine therapy (ET) ± ribociclib. Presented at the San Antonio Breast Cancer Symposium, December 9, 2020. Abstract #PD2-04.
12. Yardley, Denise, A. et. al. Overall survival (OS) in patients (pts) with advanced breast cancer (ABC) with visceral metastases (mets), including those with liver mets, treated with ribociclib (RIB) plus endocrine therapy (ET) in the MONALEESA (ML) -3 and -7 trials. Presented at the American Society of Clinical Oncology (ASCO) Annual Meeting. Abstract #1054.
13. O’Shaughnessy J et al. Overall survival subgroup analysis by metastatic site from the Phase III MONALEESA-2 study of first-line ribociclib + letrozole in postmenopausal patients with HR+/HER2− advanced breast cancer. Presented at the San Antonio Breast Cancer Symposium, December 7-10, 2021. Abstract #GS2-01.
14. Novartis Data on File. Novartis Pharmaceuticals Corp: 2021.

城中活動

2024-12-23 10:30 上午 英文藝術字書法創作班 
2024-12-16 11:00 上午 花藝班之聖誕篇🎄

疑難排解

會員註冊


或許你會想看
【大腸癌治療】後線晚期大腸癌系列:聯合治療為患者重燃新曙光 |謝耀昌醫生
大腸癌是本港三大常見癌症之一,2024年發表的最新癌症統計顯示,腸癌新症數目高達5,190宗,死亡個案達2,2 […]
中大醫學院獲李嘉誠基金會捐贈亞洲首台 Histotripsy 2.0 系統 共 30 名患者獲資助接受組織碎化技術治肝癌
香港中文大學(中大)醫學院獲李嘉誠基金會(基金會)捐贈亞洲首台 Histotripsy 2.0 系統,將於明年 […]
港大醫學院統合分析指高危EB病毒譜系與南中國鼻咽癌風險密切相關
香港大學李嘉誠醫學院(港大醫學院)研究團隊發現,特定的EB病毒(Epstein-Barr virus)變異體與 […]
【預防HPV】衞生署十二月二日開展人類乳頭瘤病毒疫苗補種計劃(第一階段)
衞生署十一月六日公布,將於十二月二日開展一次性人類乳頭瘤病毒(HPV)疫苗(又稱子宮頸癌疫苗)補種計劃(第一階 […]
【免費肺癌篩查計劃】癌症資訊網慈善基金啟動新一輪免費肺癌篩查計劃 擴大名額助高風險人士早期發現肺癌 提高治癒機會
癌症資訊網慈善基金啟動新一輪免費肺癌篩查計劃 擴大名額助高風險人士早期發現肺癌 提高治癒機會 【2024年11 […]
【癌症治療】充份理解進行免疫細胞治療所面對的風險
近月有藝人分享前往泰國進行免疫細胞治療 再次引起社群、同路人之間的討論 香港主要是緊隨 FDA 的指引,只有C […]
【脊椎健康】養和發布關於港人脊椎健康調查結果 近九成受訪者受脊椎問題困擾影響日常生活
(2024年10月28日,香港)養和醫療集團(養和)於今年8至9月期間進行了一項有關脊椎健康的問卷調查,共收集 […]
【肝炎肝癌】為己又為人 丙肝可斷尾 盡早醫免傷「肝」|劉煥楠醫生
丙型肝炎是一種由病毒感染引致的肝炎,不似乙型肝炎般普遍,但破壞力卻同樣厲害,可以誘發肝硬化及肝癌等嚴重併發症。 […]
【世界肺癌大會】癌症資訊網慈善基金首次參與世界肺癌大會 分享低劑量肺部電腦掃描肺癌篩查計劃成果
癌症資訊網慈善基金首次參與世界肺癌大會(WCLC) 分享低劑量肺部電腦掃描肺癌篩查計劃成果 瀏覽 “ […]
【精準醫療】行動基因香港與癌症資訊網合作 推廣癌症患者的精準醫療
行動基因香港與癌症資訊網合作 推廣癌症患者的精準醫療 Sep 11th, 2024 香港–行動基因 […]
香港大學李嘉誠醫學院獲捐贈亞洲首部國際級創新儀器 突破性組織碎化技術 高效益、無創、無痛肝癌最新療法
香港大學李嘉誠醫學院(港大醫學院)獲李嘉誠基金會(基金會)捐贈亞洲首部突破性醫療儀器Histotripsy系統 […]