「精子」助抗癌成功　科學家：可減副作用

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「精子」助抗癌成功　科學家：可減副作用

19-12-2017

「精子」助抗癌成功　科學家：可減副作用

十二月 18, 2017 •健康, 生活科技 •

精子擁有活力游到卵子以傳宗接代，但他的活躍性原來還有其他用途。德國有科學家小組發現，精子可來傳送藥物。他們成功把抗癌藥注入精子內，然後帶到癌腫瘤旁，讓精子把藥物送入腫瘤內。科學家正研究這種全新的癌症治療方式，希望能大大減低抗癌藥物對病人的副作用，而且可無限制地使用藥物。

在德國萊布尼茲物料研究中心（Leibnitz Institute for Solid State ans Materials Research），首席科學家 Haifeng Xu 以及其團隊發現一種可以殺死癌細胞但不會殺死病人的新治療方法，並刊登於 ACSNANO 科學網站。他們首先把藥物注入精子內，然後把精子存放於一個叫「Spermbots」的載體，這個載體可通過磁力控制其移動。

▲利用載體與磁力以移動精子

▲載體解除後精子可進入腫瘤內

在實驗室的培養皿當中，科學家把載體利用磁力移動到癌腫瘤旁邊，磁力可把載體本身拆除，而精子會向腫瘤內部進入。他們做了這個實驗 3 日的時間，發現有 87％癌細胞死亡。科學家指出，這種方法如能成功在人體內實行，可減低疲勞、嘔吐等治療時常見的副作用。

▲透過磁力可將載體運送到腫瘤旁邊，並開啟活門放行

▲在今次試驗中癌細胞的變化

科學家 Haifeng Xu 指出，這種方法除了可治療癌症，

亦可能能夠應用在子宮內膜異位症以及異位妊娠等治療中。

資料來源：Bigthink , unwire.hk

https://unwire.hk/2017/12/18/spermbotskillcancer/life-tech/

Hijacked sperm carry chemo drugs to cervical cancer cells

Directed delivery

Georges Kyrillos / Alamy

By Alice Klein

There’s a new use for sperm – delivering cancer drugs.

Standard chemotherapy is toxic to both cancer cells and normal cells, leading to symptoms like nausea, and limiting the dose a person can receive. But if chemotherapy drugs specifically targeted tumours, we could avoid this.

Haifeng Xu at the Leibniz Institute for Solid State and Materials Research in Germany and his team are experimenting with using sperm cells to take drugs to cancers in the female reproductive tract. When they loaded sperm cells with doxorubicin, a common chemo agent, and released them in a dish containing mini cervical cancer tumours, the sperm swam towards the tumours, killing 87 per cent of their cells within three days.

The team then fitted sperm with tiny four-armed magnetic harnesses that allowed them to be guided by magnets. When the sperm hit a solid tumour, the arms sprung open, releasing the sperm and allowing them to swim into the tumour.

As well as cancer, spermbots might be useful for treating other conditions affecting the female reproductive tract such as endometriosis or ectopic pregnancies, says Xu.

資料來源：Newscientist

https://www.newscientist.com/article/2156525-hijacked-sperm-carry-chemo-drugs-to-cervical-cancer-cells/

癌症