文章
醫療新知 > 美國專家研發程式助發現胰臟癌

美國專家研發程式助發現胰臟癌

07-09-2017

胰臟癌是死亡率最高的癌症之一,少於一成病人能活多過5年,而且病徵不明顯。美國華盛頓大學的研究人員研發了一個手機應用程式,透過分析自拍照中眼白的膽紅素水平,從而得知患胰臟癌的機率。

英國《每日郵報》報道,眼白變黃是胰臟癌的其中一個病徵,那是因為腫瘤影響體內膽紅素上升,但如果看到眼睛變黃,通常已經是癌症後期。

這個名叫BiliScreen的應用程式,能夠分析自拍者眼睛的照片,探測眼白的膽紅素水平。程式在首次的臨床測試中成功率達八成七,同時較傳統的驗血方法更方便、便宜。

程式仍需作進一步測試,希望能於九月中推出。研究人員希望能幫助不幸患上胰臟癌的人及早發現,把握時間接受治療,增加生存機會。

 

New app could use smartphone selfies to screen for pancreatic cancer

BiliScreen is a new smartphone app that can screen for pancreatic cancer by having users snap a selfie. It’s shown here with a 3-D printed box that helps control lighting conditions to detect signs of jaundice in a person’s eye.

 

BiliScreen is a new smartphone app that is designed to screen for pancreatic cancer by having users snap a selfie. It’s shown here with a 3-D printed box that helps control lighting conditions to detect signs of jaundice in a person’s eye.Dennis Wise/University of Washington

Pancreatic cancer has one of the worst prognoses — with a five-year survival rate of 9 percent — in part because there are no telltale symptoms or non-invasive screening tools to catch a tumor before it spreads.

Now, University of Washington researchers are developing an app that could allow people to easily screen for pancreatic cancer and other diseases — by snapping a smartphone selfie.

BiliScreen uses a smartphone camera, computer vision algorithms and machine learning tools to detect increased bilirubin levels in a person’s sclera, or the white part of the eye. The app is described in a paper to be presented Sept. 13 at Ubicomp 2017, the Association for Computing Machinery’s International Joint Conference on Pervasive and Ubiquitous Computing.

One of the earliest symptoms of pancreatic cancer, as well as other diseases, is jaundice, a yellow discoloration of the skin and eyes caused by a buildup of bilirubin in the blood. The ability to detect signs of jaundice when bilirubin levels are minimally elevated — but before they’re visible to the naked eye — could enable an entirely new screening program for at-risk individuals.

In an initial clinical study of 70 people, the BiliScreen app — used in conjunction with a 3-D printed box that controls the eye’s exposure to light — correctly identified cases of concern 89.7 percent of the time, compared to the blood test currently used.

“The problem with pancreatic cancer is that by the time you’re symptomatic, it’s frequently too late,” said lead author Alex Mariakakis, a doctoral student at the Paul G. Allen School of Computer Science & Engineering. “The hope is that if people can do this simple test once a month — in the privacy of their own homes — some might catch the disease early enough to undergo treatment that could save their lives.”

BiliScreen builds on earlier work from the UW’s Ubiquitous Computing Lab, which previously developed BiliCam, a smartphone app that screens for newborn jaundice by taking a picture of a baby’s skin. A recent study in the journal Pediatrics showed BiliCam provided accurate estimates of bilirubin levels in 530 infants.

In collaboration with UW Medicine doctors, the UbiComp lab specializes in using cameras, microphones and other components of common consumer devices — such as smartphones and tablets — to screen for disease.

BiliScreen provides estimates of bilirubin levels in a person’s blood. Elevated levels can be an early warning sign for pancreatic cancer, hepatitis and other diseases.

 

BiliScreen provides estimates of bilirubin levels in a person’s blood. Elevated levels can be an early warning sign for pancreatic cancer, hepatitis and other diseases.Dennis Wise/University of Washington

The blood test that doctors currently use to measure bilirubin levels — which is typically not administered to adults unless there is reason for concern — requires access to a health care professional and is inconvenient for frequent screening. BiliScreen is designed to be an easy-to-use, non-invasive tool that could help determine whether someone ought to consult a doctor for further testing. Beyond diagnosis, BiliScreen could also potentially ease the burden on patients with pancreatic cancer who require frequent bilirubin monitoring.

In adults, the whites of the eyes are more sensitive than skin to changes in bilirubin levels, which can be an early warning sign for pancreatic cancer, hepatitis or the generally harmless Gilbert’s syndrome. Unlike skin color, changes in the sclera are more consistent across all races and ethnicities.

Yet by the time people notice the yellowish discoloration in the sclera, bilirubin levels are already well past cause for concern. The UW team wondered if computer vision and machine learning tools could detect those color changes in the eye before humans can see them.

“The eyes are a really interesting gateway into the body — tears can tell you how much glucose you have, sclera can tell you how much bilirubin is in your blood,” said senior author Shwetak Patel, the Washington Research Foundation Entrepreneurship Endowed Professor in Computer Science & Engineering and Electrical Engineering.  “Our question was: Could we capture some of these changes that might lead to earlier detection with a selfie?”

BiliScreen uses a smartphone’s built-in camera and flash to collect pictures of a person’s eye as they snap a selfie. The team developed a computer vision system to automatically and effectively isolate the white parts of the eye, which is a valuable tool for medical diagnostics. The app then calculates the color information from the sclera — based on the wavelengths of light that are being reflected and absorbed — and correlates it with bilirubin levels using machine learning algorithms.

The UW team tested two different accessories for BiliScreen: a 3-D printed box to control lighting conditions and glasses that help the app calibrate colors. The goal is to remove the need for additional accessories, potentially by mining data from facial pictures.

 

The UW team tested two different accessories for BiliScreen: a 3-D printed box to control lighting conditions and glasses that help the app calibrate colors. The goal is to remove the need for additional accessories, potentially by mining data from facial pictures.Dennis Wise/University of Washington

To account for different lighting conditions, the team tested BiliScreen with two different accessories: paper glasses printed with colored squares to help calibrate color and a 3-D printed box that blocks out ambient lighting. Using the app with the box accessory — reminiscent of a Google Cardboard headset — led to slightly better results.

Next steps for the research team include testing the app on a wider range of people at risk for jaundice and underlying conditions, as well as continuing to make usability improvements — including removing the need for accessories like the box and glasses.

“This relatively small initial study shows the technology has promise,” said co-author Dr. Jim Taylor, a professor in the UW Medicine Department of Pediatrics whose father died of pancreatic cancer at age 70.

“Pancreatic cancer is a terrible disease with no effective screening right now,” Taylor said. “Our goal is to have more people who are unfortunate enough to get pancreatic cancer to be fortunate enough to catch it in time to have surgery that gives them a better chance of survival.”

Co-authors include Allen School undergraduate student Megan A. Banks, research study coordinator Lauren Phillipi and assistant professor of medicine Lei Yu.

The research was funded by the National Science Foundation, the Coulter Foundation and endowment funds from the Washington Research Foundation.

For more information, contact the research team at uwbiliscreen@gmail.com or Mariakakis at atm15@cs.washington.edu.

城中活動

2019-03-30 2:00 pm 乳癌關顧組茶聚
2019-03-22 2:30 pm 鏡花歲月展芳情

疑難排解

會員註冊


或許你會想看
一種新葯能破壞癌細胞生物鍾 / ScienceDailyCancer has a biological clock and this drug may keep it from ticking
一種新葯能破壞癌細胞生物鍾 北京新浪網 (2019-01-26 10:11) 新華社洛杉磯1月25日電(記者譚晶晶)美國南加州大學和日本名古屋大學的研究人員日前合作研發出一種新葯,可通過破壞癌細胞生物鍾的方式來抑制癌細胞生長。 [...]
FDA 批准可以抑制 17 種腫瘤的新藥上市,治癒癌症的代價是一年要花上千萬台幣
FDA 批准可以抑制 17 種腫瘤的新藥上市,治癒癌症的代價是一年要花上千萬台幣   美國食品和藥物管理局(The Food and Drug Administration,簡稱 FDA)在星期一的時候批准一款抗癌新藥 [...]
Google以深度學習協助檢測胸腺癌轉移,時間少一半、錯誤率降2倍
Google以深度學習協助檢測胸腺癌轉移,時間少一半、錯誤率降2倍   病理學家在LYNA的協助下,在主觀上認為工作變得更容易,並且每張幻燈片的檢驗時間從2分鐘縮短至1分鐘,而且判斷出錯率降低2倍。   [...]
免疫細胞療法抗癌 專家:非人人有效
免疫細胞療法抗癌 專家:非人人有效   無藥可用的癌症患者未來可望用細胞治療,不用再跨海求援。萬芳醫院癌症中心主任賴基銘今天說,胰臟癌、肝癌、膀胱癌等癌友未來都有機會可用,但並非人人都有效。 [...]
抹茶可醫乳癌?英研究發現抹茶可令乳癌細胞休眠死去 / Could matcha green tea be used to treat cancer? ‘Striking’ results show it kills cancer cells by stopping them from refuelling
抹茶可醫乳癌?英研究發現抹茶可令乳癌細胞休眠死去 19:21 2018/09/02   英國一項研究發現,抹茶萃取物可破壞乳癌細胞。   [...]
中大醫學院師法耶魯開文物觀賞課
  中大的「文物觀賞課程」由中大醫學院助理院長(常務)趙偉仁(左)及中大文物館館長姚進莊(右)負責教授。圖中為中大醫學院院長陳家亮   [...]
丹麥人工卵巢新科技 可望協助癌癒婦女懷孕  / Artificial ovaries could help young cancer patients preserve their fertility, and this is a game-changer
丹麥人工卵巢新科技 可望協助癌癒婦女懷孕  (法新社資料圖片)   丹麥科學加宣布研發人工卵巢新技術,將來可望有助曾接受化療、放射治療等婦女重拾生育能力。 [...]
患上乳癌後,妳要怎樣照顧自己的身體?
患上乳癌後,妳要怎樣照顧自己的身體?     治療乳癌可能是一個漫長的過程,但是在生活上和治療上都有一些方法可以助妳減少不適,讓妳能較安然和積極地渡過各個療程。     [...]
《自然》重磅:肝癌大突破!拉斯克獎大牛發現全新抑癌蛋白,有望突破肝癌診療的瓶頸 | 科學大發現
《自然》重磅:肝癌大突破!拉斯克獎大牛發現全新抑癌蛋白,有望突破肝癌診療的瓶頸 | 科學大發現   [...]
轉移性乳癌的治療
轉移性乳癌的治療     轉移性乳癌指癌細胞已由乳房擴散至其他器官(第 4 期),一般不適合以手術切除,故治療方法多以藥物治療為主,可能包括化療、標靶藥物或荷爾蒙治療。視乎情況亦有可能配以放射治療。 [...]
早期乳癌的治療
早期乳癌的治療             早期乳癌泛指腫瘤可以手術切除 (一般包括第 1-3 [...]
HER2 型乳癌是什麼?
HER2 型乳癌是什麼?               在本港,約 20%乳癌個案是「較惡」的 HER2 型乳癌。HER2 [...]