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國際視野 / 癌症資訊網編輯室 > ONX-0801, 卵巢癌治療藥物有突破性研發

ONX-0801, 卵巢癌治療藥物有突破性研發

08-06-2017
 
澳洲每年有1400位女性死於卵巢​癌. 
研究者稱，ONX-0801(一種試驗藥物)是卵巢​癌治療領域的重大研究進展。
 
此藥是過去十年研發中的最大突破。15位患者參加全球首次ONX-0801的臨床試驗，其中7位患者的腫瘤大幅縮減。這些患者預期壽命幾個月，對現存的藥物及治療方案無反應。
 
更激動人心的是，此藥在攜帶卵巢​癌某致病基因的女性中發揮治療藥效。15位測試者的實驗小組中，10位女性中有7位對ONX-0801有反應。
 
ONX-0801偽裝成葉酸，進入癌細胞內，抑制胸苷酸合成酶，這是新型藥物的首次嘗試。此研究的負責人Udai Banerji（英國癌症研究所藥物發展部副部長兼倫敦皇家Marsden NHS基金會副會長）表示，“這是全新的作用機制。”
 
卵巢​癌細胞有異常大量葉酸受體——葉酸受體α，也就是說此療法能有效對抗卵巢​癌細胞。
 
現存的治療方案對卵巢​癌末期患者無效，而服用ONX-0801，伴有極小的副作用，她們可延長半年多的壽命。Banerji表示，“過去十年，這從未實現。”
 
倘若後續臨床試驗的結果和首次試驗的結果相似，ONX-0801可能將應用於卵巢​癌初期。Banerji認為，ONX-0801在此階段藥效發揮更佳。
 
新療法專攻癌細胞，不幹涉健康細胞。這意味著，病患不會遭受化學治療帶來的副作用，如感染、腹瀉、神經損傷及掉髮等。
 
研究者也創建了測試，探測對ONX-0801反應最敏感的細胞。也就是說，醫生能夠識別接受此藥物治療獲益最大的那群女性。Banerji表示，“當然，現在為時尚早，我非常期待這個療法的後期臨床試驗。”
 
卵巢​癌的症狀較模糊，很多患者求醫時，已是癌症晚期。約60%的女性確診時，癌細胞已擴散至全身，無法治愈。
 
癌症協會的報告指出，在澳洲，僅44%的卵巢​癌患者在確診后能存活5年。卵巢​癌症狀包括: 腹脹；食欲不振或很快有飽腹感；尿頻或尿急；背部、腹部或骨盆疼痛；便秘；月經失調；疲憊；消化不良；性行為期間疼痛等。
 
關於卵巢​癌的更多信息，請訪問澳洲癌症協會官網 
http://www.cancer.org.au/about-cancer/types-of-cancer/ovarian-cancer.html
 
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