文章
醫療新知 > 一種新葯能破壞癌細胞生物鍾 / ScienceDailyCancer has a biological clock and this drug may keep it from ticking

一種新葯能破壞癌細胞生物鍾 / ScienceDailyCancer has a biological clock and this drug may keep it from ticking

28-01-2019

一種新葯能破壞癌細胞生物鍾
北京新浪網 (2019-01-26 10:11)

新華社洛杉磯1月25日電(記者譚晶晶)美國南加州大學和日本名古屋大學的研究人員日前合作研發出一種新葯,可通過破壞癌細胞生物鍾的方式來抑制癌細胞生長。

眾所周知,擾亂生物鍾節奏會損害人體健康,對細胞的生物鍾也是如此。如果能擾亂癌細胞的生物鍾,理論上可以損害或消滅這些癌細胞。

研究團隊在新一期美國《科學進展》雜誌上報告,他們對人體腎癌和小鼠急性髓細胞白血病的癌細胞開展了研究。結果發現,一種名為GO289的分子可以通過阻礙癌細胞的生物鍾從而放慢其生長周期,同時對健康細胞幾乎沒有影響。

研究人員說,GO289藥物與一種控制細胞生物鍾的酶能相互作用,這種相互作用可以破壞對細胞生長和存活至關重要的其他4種蛋白質的功能。

南加州大學麥克爾森趨同生物科學中心主任史蒂夫·凱表示,在某些癌症中,疾病控制了生物鍾機制並刺激癌細胞生長,而GO289可以干擾這些過程並阻止癌症的發展,這種藥物「可能成為消滅癌症的有效新武器」。


ScienceDailyCancer has a biological clock and this drug may keep it from ticking
A promising drug slows cancer’s circadian clock, halts its spread

Date:January 23, 2019
Source: University of Southern California
Summary: Scientists find and test a promising drug that stops cancer by interfering with the cancer cells’ metabolism and other circadian-related functions.

 

The photograph shows an enlarged view of human bone cancer cells, which stopped growing when a drug molecule, GO289, jammed their circadian rhythm.
Credit: USC Michelson Center for Convergent Bioscience

 

A new drug shows potential to halt cancer cells’ growth by stunting the cells’ biological clock.

The findings from scientists at the USC Michelson Center for Convergent Bioscience and Nagoya University’s Institute of Transformative BioMolecules (ITbM) advance a burgeoning area of research: turning the body’s circadian rhythms against cancer.

Their study, conducted on human kidney cancer cells and on acute myeloid leukemia in mice, was published Jan. 23 in the journal Science Advances.

Scientists know that disrupting sleep and other elements of humans’ circadian rhythm can harm health. The same is true for the circadian clock of cells themselves. If researchers could disturb the circadian clock of cancer cells, they theorize, they could potentially hurt or kill those cells.

The scientists found that a molecule named GO289 targets an enzyme that controls the cell’s circadian rhythm. This drug-protein interaction then disrupts the functions of four other proteins that are important for cell growth and survival.

In effect, GO289 can jam the cogs of the cell’s circadian clock, slowing its cycles. And it can do so with little impact to healthy cells.

“In some cancers, the disease takes over the circadian clock mechanism and uses it for the evil purpose of helping itself grow,” said Steve Kay, director of convergent biosciences at the USC Michelson Center and USC Provost Professor of Neurology, Biomedical Engineering and Biological Sciences. “With GO289, we can interfere with those processes and stop the cancer from growing.”

Kay is among several scientists from USC Dornsife College of Letters, Arts and Sciences, USC Viterbi School of Engineering and Keck School of Medicine at USC who are collaborating across multiple disciplines to find new solutions for treating cancer, neurological disease and cardiovascular disease.

 

Finding the right candidate

On its initial interactions with human bone cancer cells, GO289 appeared to slow the tumors’ circadian clock as it targeted an enzyme, named CK2.

To see if GO289 consistently hindered other cancers in the same way, the scientists then tested it on human kidney cancer cells and on mice with acute myeloid leukemia. They found that GO289 specifically affected cancer cell metabolism and other circadian-related functions that normally would enable the cancer to grow and spread.

Kay is optimistic about the findings. “This could become an effective new weapon that kills cancer,” he said.

 

文章來自: (中) 北京新浪網

(Eng) ScienceDaily

城中活動

2024-01-03 3:45 下午 ANIMAL FLOW
2023-12-22 10:30 上午 12月植物染工作坊

疑難排解

會員註冊


或許你會想看
養和質子治療中心盛大開幕 標誌著香港在精準癌症治療的領域上邁出重要的一步
養和質子治療中心盛大開幕 標誌著香港在精準癌症治療的領域上邁出重要的一步 養和質子治療中心設有兩間設備先進的質 […]
首項粵港澳大灣區跨境醫療銜接服務合作啟動禮
隨著中國内地與香港正式通關,往來兩地的人次顯著上升, 大眾對跨境優質醫療服務的需求亦日益殷切。保誠保險有限公司 […]
【突破膽管癌治療局限】蔣子樑醫生
膽管是人體內一個細小器官,一旦出現癌變,致命率卻是極高,過往更因缺乏相關藥物,令群醫束手無策。幸而這個劣勢,隨 […]
養和、港大醫學院及香港遺傳性乳癌家族資料庫 聯合推動本港遺傳性乳癌及卵巢癌基因突變的研究
  (2023 年 11 月 15 日,香港)養和醫療集團(養和)、香港大學李嘉誠醫學院 (港大醫學 […]
兌現「5日內開始電療」承諾 香港港安醫院腫瘤中心助力患者把握黃金治療期
【2023年11月10日,香港】香港港安醫院腫瘤中心(Hong Kong Adventist Hospital […]
醫管局指大灣區醫療人才交流計劃內地醫護工作符合期望
醫管局大灣區醫療人才交流計劃實施近半年,10名來自廣東省三甲醫院的醫生,分別於九龍中、九龍西及新界西醫院聯網的 […]
港大醫學院發現癌細胞間互動模式 有望為肝癌治療領域帶來新的突破
香港大學李嘉誠醫學院(港大醫學院)臨床醫學學院病理學系任蕙蘋教授帶領的團隊近期取得重大突破,首次揭示循環小細胞 […]
在家採樣檢測 HPV 助早篩子宮頸癌
子宮頸癌是本港常見癌症及香港女性致命癌症之一,據世衛資料,95%子宮頸癌病例由HPV引發。除了傳統HPV和柏氏 […]
乙型肝炎民間篩查見成果 梁熙籲政府資助市民篩查
民建聯衛生事務發言人、立法會議員梁熙早前與社區組織銀騎士,於去年10月在柴灣漁灣邨舉辦「乙型肝炎社區篩查活動」 […]
香港科技園公司與美國默沙東藥廠攜手為製藥業界創造以數據驅動的新方案
(香港,2023 年 8 月 11 日) – 香港科技園公司(科技園公司)夥拍美國默沙東藥廠(默沙東)舉辦「醫 […]
大灣區醫療專業發展協會成立 推動粵港澳醫療合作
大灣區醫療專業發展協會昨日在香港舉行成立典禮,全國政協常委高永文榮任該會榮譽會長。協會旨在推動香港與大灣區醫療 […]
浸大發現草藥提取化合物「異甘草素」具備治療胰臟癌潛力
一項由香港浸會大學(浸大)科學家領導的研究發現,從中草藥「甘草」提取的一種類黃酮物質「異甘草素」,可抑制胰臟癌 […]