文章
醫療新知 > 一種新葯能破壞癌細胞生物鍾 / ScienceDailyCancer has a biological clock and this drug may keep it from ticking

一種新葯能破壞癌細胞生物鍾 / ScienceDailyCancer has a biological clock and this drug may keep it from ticking

28-01-2019

一種新葯能破壞癌細胞生物鍾
北京新浪網 (2019-01-26 10:11)

新華社洛杉磯1月25日電(記者譚晶晶)美國南加州大學和日本名古屋大學的研究人員日前合作研發出一種新葯,可通過破壞癌細胞生物鍾的方式來抑制癌細胞生長。

眾所周知,擾亂生物鍾節奏會損害人體健康,對細胞的生物鍾也是如此。如果能擾亂癌細胞的生物鍾,理論上可以損害或消滅這些癌細胞。

研究團隊在新一期美國《科學進展》雜誌上報告,他們對人體腎癌和小鼠急性髓細胞白血病的癌細胞開展了研究。結果發現,一種名為GO289的分子可以通過阻礙癌細胞的生物鍾從而放慢其生長周期,同時對健康細胞幾乎沒有影響。

研究人員說,GO289藥物與一種控制細胞生物鍾的酶能相互作用,這種相互作用可以破壞對細胞生長和存活至關重要的其他4種蛋白質的功能。

南加州大學麥克爾森趨同生物科學中心主任史蒂夫·凱表示,在某些癌症中,疾病控制了生物鍾機制並刺激癌細胞生長,而GO289可以干擾這些過程並阻止癌症的發展,這種藥物「可能成為消滅癌症的有效新武器」。


ScienceDailyCancer has a biological clock and this drug may keep it from ticking
A promising drug slows cancer’s circadian clock, halts its spread

Date:January 23, 2019
Source: University of Southern California
Summary: Scientists find and test a promising drug that stops cancer by interfering with the cancer cells’ metabolism and other circadian-related functions.

 

The photograph shows an enlarged view of human bone cancer cells, which stopped growing when a drug molecule, GO289, jammed their circadian rhythm.
Credit: USC Michelson Center for Convergent Bioscience

 

A new drug shows potential to halt cancer cells’ growth by stunting the cells’ biological clock.

The findings from scientists at the USC Michelson Center for Convergent Bioscience and Nagoya University’s Institute of Transformative BioMolecules (ITbM) advance a burgeoning area of research: turning the body’s circadian rhythms against cancer.

Their study, conducted on human kidney cancer cells and on acute myeloid leukemia in mice, was published Jan. 23 in the journal Science Advances.

Scientists know that disrupting sleep and other elements of humans’ circadian rhythm can harm health. The same is true for the circadian clock of cells themselves. If researchers could disturb the circadian clock of cancer cells, they theorize, they could potentially hurt or kill those cells.

The scientists found that a molecule named GO289 targets an enzyme that controls the cell’s circadian rhythm. This drug-protein interaction then disrupts the functions of four other proteins that are important for cell growth and survival.

In effect, GO289 can jam the cogs of the cell’s circadian clock, slowing its cycles. And it can do so with little impact to healthy cells.

“In some cancers, the disease takes over the circadian clock mechanism and uses it for the evil purpose of helping itself grow,” said Steve Kay, director of convergent biosciences at the USC Michelson Center and USC Provost Professor of Neurology, Biomedical Engineering and Biological Sciences. “With GO289, we can interfere with those processes and stop the cancer from growing.”

Kay is among several scientists from USC Dornsife College of Letters, Arts and Sciences, USC Viterbi School of Engineering and Keck School of Medicine at USC who are collaborating across multiple disciplines to find new solutions for treating cancer, neurological disease and cardiovascular disease.

 

Finding the right candidate

On its initial interactions with human bone cancer cells, GO289 appeared to slow the tumors’ circadian clock as it targeted an enzyme, named CK2.

To see if GO289 consistently hindered other cancers in the same way, the scientists then tested it on human kidney cancer cells and on mice with acute myeloid leukemia. They found that GO289 specifically affected cancer cell metabolism and other circadian-related functions that normally would enable the cancer to grow and spread.

Kay is optimistic about the findings. “This could become an effective new weapon that kills cancer,” he said.

 

文章來自: (中) 北京新浪網

(Eng) ScienceDaily

城中活動

2019-03-01 7:00 pm 藝術治療計劃
2019-01-25 10:30 am 送狗迎豬齊揮春
2019-01-09 1:00 am 旋轉木馬義賣

疑難排解

會員註冊


或許你會想看
一種新葯能破壞癌細胞生物鍾 / ScienceDailyCancer has a biological clock and this drug may keep it from ticking
一種新葯能破壞癌細胞生物鍾 北京新浪網 (2019-01-26 10:11) 新華社洛杉磯1月25日電(記者譚晶晶)美國南加州大學和日本名古屋大學的研究人員日前合作研發出一種新葯,可通過破壞癌細胞生物鍾的方式來抑制癌細胞生長。 [...]
FDA 批准可以抑制 17 種腫瘤的新藥上市,治癒癌症的代價是一年要花上千萬台幣
FDA 批准可以抑制 17 種腫瘤的新藥上市,治癒癌症的代價是一年要花上千萬台幣   美國食品和藥物管理局(The Food and Drug Administration,簡稱 FDA)在星期一的時候批准一款抗癌新藥 [...]
Google以深度學習協助檢測胸腺癌轉移,時間少一半、錯誤率降2倍
Google以深度學習協助檢測胸腺癌轉移,時間少一半、錯誤率降2倍   病理學家在LYNA的協助下,在主觀上認為工作變得更容易,並且每張幻燈片的檢驗時間從2分鐘縮短至1分鐘,而且判斷出錯率降低2倍。   [...]
免疫細胞療法抗癌 專家:非人人有效
免疫細胞療法抗癌 專家:非人人有效   無藥可用的癌症患者未來可望用細胞治療,不用再跨海求援。萬芳醫院癌症中心主任賴基銘今天說,胰臟癌、肝癌、膀胱癌等癌友未來都有機會可用,但並非人人都有效。 [...]
抹茶可醫乳癌?英研究發現抹茶可令乳癌細胞休眠死去 / Could matcha green tea be used to treat cancer? ‘Striking’ results show it kills cancer cells by stopping them from refuelling
抹茶可醫乳癌?英研究發現抹茶可令乳癌細胞休眠死去 19:21 2018/09/02   英國一項研究發現,抹茶萃取物可破壞乳癌細胞。   [...]
中大醫學院師法耶魯開文物觀賞課
  中大的「文物觀賞課程」由中大醫學院助理院長(常務)趙偉仁(左)及中大文物館館長姚進莊(右)負責教授。圖中為中大醫學院院長陳家亮   [...]
丹麥人工卵巢新科技 可望協助癌癒婦女懷孕  / Artificial ovaries could help young cancer patients preserve their fertility, and this is a game-changer
丹麥人工卵巢新科技 可望協助癌癒婦女懷孕  (法新社資料圖片)   丹麥科學加宣布研發人工卵巢新技術,將來可望有助曾接受化療、放射治療等婦女重拾生育能力。 [...]
患上乳癌後,妳要怎樣照顧自己的身體?
患上乳癌後,妳要怎樣照顧自己的身體?     治療乳癌可能是一個漫長的過程,但是在生活上和治療上都有一些方法可以助妳減少不適,讓妳能較安然和積極地渡過各個療程。     [...]
《自然》重磅:肝癌大突破!拉斯克獎大牛發現全新抑癌蛋白,有望突破肝癌診療的瓶頸 | 科學大發現
《自然》重磅:肝癌大突破!拉斯克獎大牛發現全新抑癌蛋白,有望突破肝癌診療的瓶頸 | 科學大發現   [...]
轉移性乳癌的治療
轉移性乳癌的治療     轉移性乳癌指癌細胞已由乳房擴散至其他器官(第 4 期),一般不適合以手術切除,故治療方法多以藥物治療為主,可能包括化療、標靶藥物或荷爾蒙治療。視乎情況亦有可能配以放射治療。 [...]
早期乳癌的治療
早期乳癌的治療             早期乳癌泛指腫瘤可以手術切除 (一般包括第 1-3 [...]
HER2 型乳癌是什麼?
HER2 型乳癌是什麼?               在本港,約 20%乳癌個案是「較惡」的 HER2 型乳癌。HER2 [...]