{"id":300,"date":"2022-02-11T08:53:38","date_gmt":"2022-02-11T08:53:38","guid":{"rendered":"https:\/\/livercancer.coom.hk\/?page_id=300"},"modified":"2022-10-31T10:15:30","modified_gmt":"2022-10-31T10:15:30","slug":"know_cll","status":"publish","type":"page","link":"https:\/\/cancerinformation.com.hk\/CLL\/know_cll\/","title":{"rendered":"\u8a8d\u8b58CLL"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"300\" class=\"elementor elementor-300\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4630e3e elementor-section-full_width elementor-section-height-min-height elementor-section-content-middle elementor-section-height-default elementor-section-items-middle\" data-id=\"4630e3e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element 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class=\"elementor-element elementor-element-543002e elementor-widget elementor-widget-image\" data-id=\"543002e\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.6.2 - 04-04-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"500\" src=\"https:\/\/cancerinformation.com.hk\/CLL\/wp-content\/uploads\/2022\/04\/\u5fae\u4fe1\u56fe\u7247_20220419154944.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/cancerinformation.com.hk\/CLL\/wp-content\/uploads\/2022\/04\/\u5fae\u4fe1\u56fe\u7247_20220419154944.jpg 1000w, 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data-element_type=\"widget\" id=\"3\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\u6709\u4ec0\u9ebd\u6210\u56e0\uff1f <\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-148c713 elementor-widget elementor-widget-text-editor\" data-id=\"148c713\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u767d\u8840\u75c5\u7684\u5177\u9ad4\u6210\u56e0\u4ecd\u5728\u7814\u7a76\u7576\u4e2d\uff0c\u7136\u800c\u76ee\u524d\u7814\u7a76\u6307\u51fa\u8207<strong><b>\u67d3\u8272\u9ad4\u7570\u5e38<\/b><\/strong>\u548c<strong><b>\u57fa\u56e0\u7a81\u8b8a<\/b><\/strong>\u6709\u95dc<sup>3<\/sup>\u3002<\/p><p><strong><em><b><i>\u67d3\u8272\u9ad4\u7570\u5e38<\/i><\/b><\/em><\/strong><\/p><p>\u4eba\u9ad4\u6bcf\u500b\u7d30\u80de\u670923\u5c0d\u67d3\u8272\u9ad4\uff0c\u662f\u57fa\u56e0\u7684\u4e3b\u8981\u8f09\u9ad4\u3002\u5982\u500b\u5225\u67d3\u8272\u9ad4\u7684\u6392\u5e8f\u6539\u8b8a\uff0c\u4e5f\u6703\u4ee4\u57fa\u56e0\u4e5f\u7522\u751f\u8b8a\u7570\uff0c\u4f7f\u767d\u8840\u7403\u7684\u5931\u63a7\u5730\u751f\u9577\uff0c\u91c0\u6210\u767d\u8840\u75c5\uff0c\u751a\u81f3\u7834\u58de\u9aa8\u9ad3<sup>3<\/sup>\u3002<\/p><p>\u67d3\u8272\u9ad4\u7570\u5e38\u5728CLL\u60a3\u8005\u4e2d\u5341\u5206\u666e\u904d\uff0c\u6700\u5e38\u898b\u70ba\u7b2c13\u5c0d\u67d3\u8272\u9ad4\u51fa\u73fe\u7f3a\u5931\u3002\u800c\u5728\u773e\u591a\u67d3\u8272\u9ad4\u7570\u5e38\u7576\u4e2d\uff0c\u4ee5\u5177\u6709\u7b2c17\u5c0d\u67d3\u8272\u9ad4\u7f3a\u5931\u7684CLL\u6700\u96e3\u8655\u7406<sup>4<\/sup>\u3002<\/p><p>\u65b0\u78ba\u8a3a\u500b\u6848\u4e2d\u7b2c17\u5c0d\u67d3\u8272\u9ad4\u51fa\u73fe\u7f3a\u5931\u7684\u60c5\u6cc1\u4e26\u4e0d\u5e38\u898b\uff0c\u53ea\u4f545-9%<sup>5<\/sup>\u3002\u7136\u800c\uff0c\u5728\u5fa9\u767c\u60a3\u8005\u7576\u4e2d\uff0c\u6709\u63a5\u8fd1\u4e00\u534a\u60a3\u8005\u7684\u7b2c17\u5c0d\u67d3\u8272\u9ad4\u51fa\u73fe\u7f3a\u5931<sup>5<\/sup>\u3002<\/p><p><strong><em><b><i>\u514d\u75ab\u7403\u86cb\u767d\u91cd\u93c8\u53ef\u8b8a\u5340 (IGHV)\u57fa\u56e0\u7a81\u8b8a<\/i><\/b><\/em><\/strong><\/p><p>IGHV\u7684\u57fa\u56e0\u7a81\u8b8a\u72c0\u614b\u662f\u8a55\u4f30CLL\u75be\u75c5\u9032\u5c55\u53ca\u9810\u5f8c\u7684\u91cd\u8981\u539f\u7d20\u4e4b\u4e00\u3002IGHV\u7121\u7a81\u8b8a\u578b\u60a3\u8005\u7684\u75c5\u60c5\u9032\u5c55\u8f03\u5feb\uff0c\u5b58\u6d3b\u671f\u8f03\u77ed<sup>6<\/sup>\u3002\u800c\u4e14\uff0c\u9019\u4e9b\u60a3\u8005\u5c0d\u5316\u5b78\u514d\u75ab\u7642\u6cd5 (chemoimmunotherapy, CIT) \u7684\u7de9\u89e3\u6301\u7e8c\u6642\u9593\u8f03\u77ed\uff0c\u6240\u4ee5\u4e00\u822c\u6703\u5efa\u8b70\u4ed6\u5011\u63a5\u53d7\u6a19\u9776\u85e5\u7269\u4f5c\u7b2c\u4e00\u7dda\u6cbb\u7642<sup>6<\/sup>\u3002<\/p><p><strong><em><b><i>T<\/i><\/b><\/em><\/strong><strong><em><b><i>P53<\/i><\/b><\/em><\/strong><strong><em><b><i>\u57fa\u56e0\u7a81\u8b8a<\/i><\/b><\/em><\/strong><\/p><p>TP53 \u57fa\u56e0\u6307\u793a\u53d7\u640d\u7d30\u80de\u662f\u5426\u61c9\u8a72\u88ab\u4fee\u5fa9\u6216\u7834\u58de\uff0c\u907f\u514d\u64c1\u6709\u4e0d\u6b63\u5e38\u907a\u50b3\u8cc7\u8a0a\u7684\u7d30\u80de\u7e7c\u7e8c\u5206\u88c2\u751f\u9577\u3002TP53\u57fa\u56e0\u7a81\u8b8a\u4ea6\u8207\u8f03\u5dee\u7684\u9810\u5f8c\u76f8\u95dc<sup>18<\/sup>\uff0c\u800c\u8d85\u904e 80% \u51fa\u73fe\u7b2c17\u5c0d\u67d3\u8272\u9ad4\u7f3a\u5931\u7684\u60a3\u8005\u4e5f\u540c\u6642\u6709 TP53\u57fa\u56e0\u7a81\u8b8a<sup>19<\/sup>\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-05c4496 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"05c4496\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c84b4a9\" data-id=\"c84b4a9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3cbe925 elementor-widget elementor-widget-heading\" data-id=\"3cbe925\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u53c3\u8003\u8cc7\u6599<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-784cf8a elementor-widget elementor-widget-text-editor\" data-id=\"784cf8a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ol class=\"ref_cont\"><li>American Cancer Society. Leukemia \u2013 Chronic Lymphocytic (CLL). What is chronic lymphocytic leukemia? Available at:\u00a0<a href=\"http:\/\/www.cancer.org\/cancer\/leukemia-chroniclymphocyticcll\/detailedguide\/leukemia-chronic-lymphocytic-what-is-cll\">http:\/\/www.cancer.org\/cancer\/leukemia-chroniclymphocyticcll\/detailedguide\/leukemia-chronic-lymphocytic-what-is-cll<\/a>.Accessed: 30 Jun 2021.<\/li><li>American Cancer Society. Leukemia \u2013 Chronic Lymphocytic (CLL). Signs and symptoms of chronic lymphocytic leukemia. Available at:<a href=\"http:\/\/www.cancer.org\/cancer\/leukemia-chroniclymphocyticcll\/detailedguide\/leukemia--chronic-lymphocytic-signs-symptoms\">http:\/\/www.cancer.org\/cancer\/leukemia-chroniclymphocyticcll\/detailedguide\/leukemia&#8211;chronic-lymphocytic-signs-symptoms<\/a>. Accessed: 30 Jun 2021.<\/li><li>American Cancer Society. Leukemia \u2013 Chronic Lymphocytic (CLL). Do We Know What Causes Chronic Lymphocytic Leukemia? Available at: https:\/\/www.cancer.org\/cancer\/chronic-lymphocytic-leukemia\/causes-risks-prevention\/what-causes.html. Accessed: 30Jun 2021.<\/li><li>D\u00f6hner H, et al. N Engl J Med 2000;343:1910-1916.<\/li><li>Gogia A, et al.\u00a0South Asian J Cancer 2019;8:40.<\/li><li>Crombie J, et al. Am J Hematol. 2017;92:1393-1397.<\/li><li>American Cancer Society. Leukemia \u2013 Chronic Lymphocytic (CLL). How Is Chronic Lymphocytic Leukemia Diagnosed? Available at: https:\/\/www.cancer.org\/cancer\/chronic-lymphocytic-leukemia\/detection-diagnosis-staging\/how-diagnosed.html. Accessed: 30Jun 2021.<\/li><li>Montserrat E, et al. Ann Oncol 1995;6:219-235.<\/li><li>Furman RR, et al. N Engl J Med 2014;370:997-1007.<\/li><li>Eichhorst B, et al. Ann Oncol 2021;32:23-33.<\/li><li>American Cancer Society. Leukemia \u2013 Chronic Lymphocytic (CLL). Typical Treatment of Chronic Lymphocytic Leukemia. Available at:https:\/\/www.cancer.org\/cancer\/chronic-lymphocytic-leukemia\/treating\/treatment-by-risk-group.html. Accessed: 30 Jun 2021.<\/li><li>Keating MJ, et al. Leuk Lymphoma 1993;11 Suppl 2:167-175.<\/li><li>Hallek M, et al. Blood 2018;131:2745-2760.<\/li><li>Marzia P, et al. \u00a0Front Immunol. 2021; 12: 686768<\/li><li>Danilov AV, et al. Br. J. Haematol 2021;193:15-25.<\/li><li>Byrd JC, et al. J Clin Oncol. 2021:JCO2101210.<\/li><li>AbbVie Inc. and Genentech USA. Living With CLL Goes Beyond Treatment. Available at: https:\/\/www.cllcancer.com\/living-with-cll. Accessed: 30Jun 2021.<\/li><li>Zenz T, et al. 2010;28:4473-4479.<\/li><li>Yu L, et al. Clin Cancer Res. 2017;23:735-745.<\/li><li>American Cancer Society. Leukemia \u2013 Chronic Lymphocytic (CLL). How Is Chronic Lymphocytic Leukemia Staged? Available at: https:\/\/www.cancer.org\/cancer\/chronic-lymphocytic-leukemia\/detection-diagnosis-staging\/staging.html. Accessed: 30 Jun 2021.<\/li><\/ol>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u8a8d\u8b58\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08CLL\uff09 \u8a8d\u8b58\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08CLL\uff09 \u4f55\u8b02\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5CLL\uff1f \u6dcb\u5df4\u7d30\u80de\u662f &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/cancerinformation.com.hk\/CLL\/know_cll\/\"> <span class=\"screen-reader-text\">\u8a8d\u8b58CLL<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"class_list":["post-300","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cancerinformation.com.hk\/CLL\/wp-json\/wp\/v2\/pages\/300","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cancerinformation.com.hk\/CLL\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cancerinformation.com.hk\/CLL\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cancerinformation.com.hk\/CLL\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cancerinformation.com.hk\/CLL\/wp-json\/wp\/v2\/comments?post=300"}],"version-history":[{"count":156,"href":"https:\/\/cancerinformation.com.hk\/CLL\/wp-json\/wp\/v2\/pages\/300\/revisions"}],"predecessor-version":[{"id":1697,"href":"https:\/\/cancerinformation.com.hk\/CLL\/wp-json\/wp\/v2\/pages\/300\/revisions\/1697"}],"wp:attachment":[{"href":"https:\/\/cancerinformation.com.hk\/CLL\/wp-json\/wp\/v2\/media?parent=300"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}